Loewe's story goes back to 1846, when Madrid was preparing for two royal marriages, that of Her Majesty Isabel II of Bourbon to the Duke of Cadizand that of the Princess Maria Luisa Fernanda to the Duke of Montpensier. That same year, a group of Spanish craftsmen opened a leather goods workshop in the most commercial district in Madrid, Lobo street (later Echegaray Street) in central Madrid. It was in 1872 when Enrique Roessberg Loewe, a German craftsman specialized in leather working, arrived in Madrid and decided to join forces with the leather workshop owners and establish the brand. Twenty years later, in 1892, E. Loewe was present in the streets of Madrid, with a large poster staking his claim and marking an entire era. It was then that the firm began to become known among the general public. Enrique Loewe brought his precision and technique and Spain its sensuality, creativity and peerless expertise in leather.

In 1905, Loewe became "Official Supplier to the Spanish Royal Crown," when Enrique Loewe Hilton was at the head of the house of Loewe, King Alfonso XII gave the family business the title of Supplier to the Royal House.